Sunday, November 8, 2020

CORONA DIARY CHAPTER 15 - October 12th to November 7th, 2020

 Thursday October 15th, 2020

 

Instead of Bloomsday, which is the sixteenth of June, it seems to be Gloomsday, though exactly where in October to pitch this unfortunate day is unclear.  We are no further on with the Covid-19 pandemic, and the government have introduced a partial lockdown situation, with three tiers, categorised as Medium, High, and Very High.  Note that there isn’t a Low.  Scenes of wild partying in Liverpool, prior to their being the only locality to get the severe treatment, are depressing.  I once wrote a song – many years ago, which included the lines

 

‘In the Autumn of the year

When the leaves are wan and brown

The cold wind of love’s displeasure

Takes the leaves and casts them down.’

 

And that is how it feels at the moment.  Hard to work up the enthusiasm to give a rendition of Monty Python’s ‘Always look on the bright side’, but perhaps tomorrow.  Yesterday, as we crossed the wee burn at Parkstone’s 8th hole in sparkling sunshine I observed to my friend how lucky we are, so I must take that thought forward.  But news last week and yesterday of new cancers in really close friends and relations is hard to take too.

 

I read James Joyce’s ‘Ulysses’ with a sense of duty in my 20s, but it had escaped my attention (maybe I had fallen asleep) that it all took place on June 16th, 1904.  Until I happened to be in Dublin on that June day in 2004 for a cardiology conference on rehabilitation.  Now Bloomsday is a big thing.

 

So, my mission to establish Gloomsday falls flat at the first hurdle.  I had thought of it this morning as ‘A touch of the Glooms’, and had imagined this related to some old radio show, but the only reference I could find is in a blog by author Misha Herwin, who says that her heroine, Letty Parker, uses this phrase.  Perhaps it was ‘The Glums’, a ground-breaking radio show (q.v.) which ran on the BBC in the 1950s.  As a child aged around six I remember my parents’ avid listening to this programme which featured a dysfunctional family consisting of Ron and Eth and Ron’s father, played by Jimmy Edwards, a handlebar-mustachioed comic who was a mainstay of 50s and 60s radio and TV.  In a subsequent TV series, ‘Whacko’, Jimmy Edwards played a headmaster who was always threatening to cane somebody.  How prehistoric does that sound now?  This week there was an article urging people in Scotland to inform on someone if they saw them smacking their child (smacking is illegal in Scotland).

 

Mention of Eisenhower and Dr Paul Dudley White in my last diary entry reminds me that it is said of senior doctors that as they age they become more interested in medical history, probably because they are no good for anything else.  But after so many years in medicine, we realise we need to take the long view.  In my own field, the doyen of Cardiology historians in the UK was Arthur Hollman.  Arthur was the consultant I was attached to on my first clinical firm at University College Hospital.  He had links to Sir Thomas Lewis, and a great interest in gardening.  Hence he was the warden of the Chelsea Physic Garden and in later life published a biography of Sir Thomas.  He continued as archivist for the British Cardiac Society (later the British Cardiovascular Society).  He was an abrupt man with no respect for reputation.  A favourite saying was ‘The books all say that, but the books are wrong.’  Once, during a presentation by a famous physician, of a child with severe hypertension, he was asked to look at the ECG, which showed gross left ventricular hypertrophy.  ‘He must have had a 4th heart sound’, he averred.  ‘I didn’t hear one, Arthur’, responded the famous physician.  ‘Then I think we’ll take it you missed it.’  Was Arthur’s response…

 

Although brusque, Arthur was one of the few physicians who had the entire firm to a tea party in his garden in Ealing at the end of our first year, and in later life, on accepting me to the cardiac fold, he addressed me as ‘Andy’.  When he cleared out some of Sir Thomas Lewis’s archival material at UCH he sent me one of Lewis’s early ECG recordings, dated 1913.

 

Walking down memory lane again, and far more trivially, Lindsay’s potato masher broke yesterday – a rivet had gone.  ‘I bought that with Green Shield Stamps’, she announced indignantly.  Although Green Shield stamps (q.v. if interested) lingered into the 1990s they were effectively dead in the water after Tesco’s, who espoused them, abandoned the stamps in a price war starting in 1977, preferring to ‘pile high and sell cheap’.

 

Sunday October 18th

 

Forgive me for being gloomy again.  The world has no response to Covid-19.  Previously successful countries have seen dramatic rises in cases, e.g. Germany, Italy, and France.  Substantial numbers of cases are again being admitted to hospitals across the UK.  I never knew we had so many professors of epidemiology, public health, and virology.  A new one pops up every day on the BBC.  There is a pretty one from Edinburgh.  Prof Gupta does not seem to have been given much column space this week.  An epidemiologist from Cambridge (I think his name is Chris Smith), who always appears surrounded by banks of electronic instruments does usually seem to be quite lucid, and points out that with low herd immunity at the moment, we are faced with a disease which kills perhaps half of a percent of all those infected, so this would mean something like a total of 300,000 dead in the UK (we are now approaching 50,000), and an impossible number being admitted to hospital.  But complete lockdown is also unconscionable, because of the economic cost, and every day we hear stories of other illnesses failing to be treated by our ‘Wonderful NHS’.  Even James Lefanu, GP, in the Telegraph, laments that every GP surgery seems to be surrounded by barbed wire.  My original thought was to follow Prof Gupta’s strategy of building up immunity among the young, and carefully shielding the old and vulnerable.  But I have not yet heard (as I hope to do) any clamouring for cutting to the chase in the vaccine stakes and getting on with an immunisation programme.  A paper from the National Institutes of Health this week in the NEJM reports excellent results in the achievement of immunity and indeed prevention of infection after SARS-Co-V2 administration in primates (Evaluation of the mRNA-1273 vaccine… etc).  Other papers address studies with different vaccines in humans.  A paper from two doctors at the FDA discussed the EUA (Emergency Use Authorisation) protocol and concluded that a two-month follow up period after the full course of vaccine administration to all participants would be adequate to allow use of a vaccine.  They do point out that there is a risk (of course) – trials of anti-shingles vaccines had a follow-up of three to four years before FDA approval.  Surely this is the only way ahead for most countries?

 

A hard hitting editorial in NEJM (‘Dying in a Vacuum’, NEJM, October 8,2020) puts the blame squarely on ‘our leaders’, a clear-cut euphemism for Donald Trump.  ‘They have taken a crisis and turned it into a tragedy.’  The introductory paragraph points out that rates of death in the USA are more than double that of Canada, and exceeds that in Japan (a country with a huge very elderly and vulnerable population) by a factor of fifty.

 

Our own leadership in the UK flounders around too, but in truth, neither political party could do any better, and Britons are just too obstreperous and bolshy to behave like the Chinese and control this epidemic.

 

Oh dear.  Sorry.  Lindsay and I had a lovely five mile walk in the New Forest this afternoon, enlivened by a couple of New Forest ponies muscling in on our picnic, and by the last mile of our walk beside the Linford Inclosure, where hundreds of thousands of crab apples covered the ground between the trees.  Perhaps next week will be better.

 

New Forest pony trying to muscle in on my lunch

Another one joins the luncheon party

Nature's bounty - New Forest crab apples




Wednesday October 21st

As I type that I belatedly realise that it is Trafalgar Day, though the recent ‘woke’ responses and cancel culture insist that Nelson was a racist so-and-so and we shouldn’t be celebrating.  Memories of the Naval School in Verdala, Cospicua, Malta, where 21st October was a big day and we always sang ‘Eternal Father, strong to save, whose arm doth bind the restless wave’ in morning assembly.

 

It’s a grey rainy day, and golf is cancelled.  Lindsay has gone with a friend to Stourhead, one of the gems in the National Trust crown.  I deal with doors, hinges, and fencing and now get some time off to write.

 

A superb article by Ambrose Evans-Pritchard in the Telegraph last week is entitled ‘Macron caught in a net as he tries to hold Brexit to ransom.’  I have mentioned AE-P before (see June 8th, the ‘Modern Day Cassandra’).  He does indeed write well, his article about the EU CFP (Common Fisheries Policy) and Macron’s insistence on ‘maximalist claims on sovereign British waters’ amounting to ‘indefensible overreach and “cakeism”’.  There are signs that Germany in particular is becoming impatient with him.  ‘Handelsblatt asks how he can expect to perpetuate a regime in which French trawlers are entitled to 84pc of the catch off the coast of Cornwall while Cornish fishermen are left with just 9pc.  It marvelled at a relationship where European boats can come to within six nautical miles of the British coast while British boats must abide by the EU’s 12-mile rule.’  Most sensible economists in Germany point out that a trade war is not in the EU’s interest.  They are concerned about tariffs (à la Trump) on what amounts to £48bn of car exports and £20bn of farm goods which flow our way from the EU.  I do like the way he writes as well.  I feel ignorant as I read his clever use of French terms – en coulisse, for example, which means ‘behind the scenes’.  Démarche means a step or an approach.  But an education at Trinity College, Cambridge and the Sorbonne has obviously helped.  The article is easily found by searching AE-P Telegraph articles.

 

Cycle sport is confusing at the moment.  We are in the last week of the Giro d’Italia, but the Vuelta a España has also started.  Primož Roglič wins stage 1 of this, so he is back to form.

 

‘It will all end in tiers’ is an appropriate pun to end up today’s entry.  Local lockdowns are the new normal, in places where incidence of Covid is high (a three tier system is now in place).  Inevitably there is political argy-bargy, the left claiming that not enough financial support is being given to the lockdowned areas, and our government are cold mean bastards (that’s what they mean, even if that is not what they say – the Labour mayor of Greater Manchester, Andy Burnham is particularly choleric).  I heard snatches of an interesting Radio 4 discussion this morning on broadcasting impartiality.  I may return to this subject.  The vested interests behind the news media companies mean that most coverage is anything but impartial, and outright lies are often promulgated as a way of reinforcing a point of view.

 

I am going to go back to:

1.      Making my lunch.

2.     Playing my guitar and working on my contemporary blues song.

3.     Making some sourdough bread.

4.     Reading Robert Harris’s ‘The Second Sleep’, which is curiously relevant to today’s apocalyptic coronavirus mood.


Saturday October 24th, 2020 

When I was young, this day was celebrated – as United Nations Day – but seems to be majorly overlooked nowadays.  I remember in the School Assembly at Haverfordwest Grammar School (Pembrokeshire, Wales), we had to stand and listen to the headmaster’s peroration about the unity of the world and how it was important to acknowledge this day.  And that is all I can remember of it.  But I also remember that the whole school was given a half-day off when an old boy was playing scrum half for Oxford in the Varsity Match – and watching it with a sense of pride on a neighbour’s very indistinct black and white TV – whereas nowadays it is only on a paid for satellite channel that one can watch this event.  The school’s motto was ‘Patriae prodesse paratus’ – which means ‘Ready to serve one’s country’, though perhaps it was brought in before Wilfred Owen’s poem which gives the lie to it: ‘Dulce et Decorum Est’, which was published in 1920.

 

What a gloomy day.  The rain started in late morning and has beaten at the windows with increasing ferocity as the day has gone on.  I have now finished The Second Sleep – very good but not ideal if the atmosphere is gloomy.

 

We have not been able to visit Lindsay’s son and his wife to celebrate their wedding anniversary.  A little boy’s parents at their son’s nursery have tested positive for Covid, so I guess we are right in not going, and they will be isolating…

 

Tuesday October 27th

 

The last few days have passed in a blur of bad weather and lack of excitement.  Tao Geoghegan Hart’s winning of the Giro d’Italia in a last gasp victory in the final time trial was an enjoyable finale to a remarkable bike race in which the 25-year old Londoner and the Australian Jai Hindley contested the last stage.  Uniquely for any Grand Tour these two were on identical times going into the final stage.  Emotions were also stirred by the finish in front of Milan’s wonderful (I refuse to call it iconic) cathedral.

 

More reading, having started ‘Go set a watchman’, the only other novel by Harper Lee, I have been decoyed by the much more readable ‘Lady in Waiting’, the autobiography of Lady Anne Glenconner.  Some idea of the difference between Lady Glenconner’s world and ours can be gleaned from the fact that, when she was a child at Holkham Hall, in Norfolk, the Palladian home of the Earls of Leicester, an enormous stately pile, the footmen would place a raw egg in a bain-marie, and walk towards the children’s nursery in the opposite wing to the kitchen.  By the time the eggs reached the nursery breakfast table they were done perfectly…

 

Sometimes it is the small articles which catch one’s attention, and which remain.  Even more so than the achievement of getting to the end of some enormous but classic tome.  In this respect, I still have the cutting of Frances Wilson’s marvellous diary introduction to last December’s Literary Review, which she entitled ‘Fay Weldon Took the Light Bulbs’.  She bought the house in which Fay Weldon wrote some of her classic works in 2001 and was somewhat surprised to find that the author had taken not only the light bulbs but the oven.  This gave her scope to write about other writer’s houses, including Dove Cottage (Wordsworth), and the homes of D H Lawrence, Emily Dickinson, Thomas Carlyle, Virginia Woolf, and Iris Murdoch.  The longest section is reserved for the havoc wreaked on Dove Cottage by its subsequent (and longest) inhabitant, Thomas De Quincey, known mainly for his ‘Confessions of an English Opium Eater’.  Now this is a book which I did read (in childhood), and the reason is that as far as I could ascertain, De Quincey is, or was, the only famous alumnus of my old school, King Edward’s, in Bath.  But perhaps we should now include the comedian and musician, Bill Bailey.  General Sir Jack Deverell should probably be included too, and Professor Chris Rapley, who was in my physics group at school, who has worked doggedly on climate change at UCL, and was one-time director of the British Antarctic Survey.  I would anticipate a knighthood at some point for Chris.

 

There are significant skirmishes in Government at the moment, with ill-feeling concerning the free school meals initiative, which the footballer Marcus Rashford wants extended into half term and the holidays, and the powers that be say are covered by extra local allowances.  But the most striking thing that seems to be part of the national mood at the moment is a very distinct anti-lockdown feeling.  People (even journalists are people) say, ‘We’ve been here once before; it didn’t work.  There isn’t much point in doing it again.’  Wales has imposed an extraordinarily strict lockdown, which they are calling a ‘Firebreak’, a lockdown by any other name.  There is enormous resentment to this.  It’s clear that the lockdown measures result in the disadvantaging of the poorest in society – self-employed; those in temporary employment; those who cannot produce tax returns from consistent employment.  And it seems that there has been about £2 billion of fraudulent claiming from the initial furlough and support schemes.

 

President Trump, of course (how could I not mention him) has told us that a vaccine is only a very short time away.  This was one of the very few of his statements which was corroborated by the U.S. Health adviser, Dr Anthony Fauci, in a superb interview with Andrew Marr on Sunday’s current affairs programme.  As well as being a clear scientific speaker, Dr Fauci’s appearance was a masterclass in how to deal with awkward or rude questions.  Challenged by Andrew Marr, for example, with the direct quotation that President Trump had called him a fool and an idiot, Fauci merely said that he didn’t think answering to such a conversation was helpful, and that he was merely doing his job to the best of his ability.

 

Thank heavens that we are only a week away from the end of the ghastly process which is the U.S. election.  We have relatives in Lancaster, Pennsylvania, and there was footage of a Trump campaign rally there.  I noted an Amish straw hat prominently in the background behind the President, no doubt an example of his all-embracing devotion to any U.S. citizen.  But I also noted an interview in the last week with an unemployed steel worker saying that Trump had not turned around the fortunes of manufacturing America, and that the steel towns were still rusting.  ‘I won’t make the same mistake again’, said the interviewee.

 

Friday October 30th

 

But sadly, good news for Trump today in that there has been a 33% upturn in the U.S. GDP, so the election is still too close to call.

 

Here at home, the atmosphere is gloomy and bleak, matching the weather, with substantial upturn in coronavirus cases, and now we do know someone in the family with Covid.  The government is criticised at every turn, but there is also panic and confusion in the Labour party.  An independent report (UK human rights watchdog) has found that there is not only anti-Semitism within the party, but that the leadership broke the law in failing to stamp it out.  Corbyn has said this is gross over-dramatisation of the true position, and Sir Keir Starmer has suspended him from the party.  Part of the problem (my own view), is that the trendy lefties espouse freedom fighters everywhere (IRA terrorists for example), irrespective of whether there is universal suffrage in the country in question.  Whereas it is fine to support Palestinians in their fight for an appropriate share of their homeland, i.e. a certain degree of anti-Zionism might be reasonable; to equate this with opprobrium for Jews in general is not appropriate.  Having trekked through the Sharah mountains in southern Jordan, and viewed to the west what Israel calls Israel and the Jordanians call ‘Occupied Palestinian Territories’, I have some sympathy with the anti-Zionists.  On the other hand, it’s hard not to have some feelings for Israel too – the country is on the hit list of virtually every other Arabic nation.  Iran in particular has its own modern day version of ‘Carthago delenda est’, the famous three-word speech of Cato in the Roman senate in the second century B.C. (it translates as ‘Furthermore Carthage must be destroyed’).

 

This week I saw the obituary of Leslie Iversen, the pharmacologist, in the newspaper.  Iversen was a brilliant scientist, whose PhD thesis on ‘The uptake and storage of noradrenaline in sympathetic nerves’ was a model of scientific method.  Unusually for a PhD thesis, it became a book which we all bought.  Leslie lectured us in Part II Pharmacology.  Everyone wanted to do their final year research with him – it was clearly such a vital and interesting field.  Sadly, I did not get to do so, working on the properties of a serotonin inhibitor called cinanserin on structures such as the smooth muscle of guinea pig ileum.  Cinanserin disappeared without trace and never made it to market.  There is a lot of serendipity in research labs – my predecessor had worked on a drug called AQ110, made by Allen & Hanbury pharmaceuticals.  Research papers quickly followed, and drug became a winner – salbutamol.  Leslie Iversen and his wife, also a talented psychoactive drug pharmacologist, became Cambridge’s golden research couple in that era of the late 60s and early 70s.  I was sorry to hear that he had died at the relatively early age of 82 (seems relatively early in that I am only 10 years younger…).

 

Another BSO concert this week, with works by Fauré, Ravel, and Saint-Saëns.  Advertisements for performances at a venue in Frome which I sometimes attend – Cheese & Grain, a converted warehouse.  Most striking are the clever names which tribute bands invent to link themselves to the originals.  We all know of the Bootleg Beatles, and the Illegal Eagles, but ‘Coldplace’ and ‘The Unravelling Wilburys’ were new ones to me.

 

Monday November 2nd

 

Weather has been generally poor but we are promised high pressure and better weather from Wednesday.  This contrasts with the gloomy state of our coronavirus situation, with the government announcing a total lockdown from Thursday.  Exact details are awaited.  The schools will not close.  Predictable unhelpful response from the teachers’ unions.  I’ve avoided numbers now for some weeks if not months, but the curve of hospital admissions shows a very substantial rise, with nearly 11,000 hospitalised Covid patients, and nearly 1,000 in ventilator beds, though whether this means assisted ventilation or full endotracheal ventilation is not stated.  Deaths are rising, though it is alleged that the mortality figures are not as high as in the first wave (by this I mean the case-fatality rate).  Opposition MPs are making hay by saying the government has not reacted fast enough to the scientific advice, but the Chief Medical Officer, Chris Whitty, did say that ‘I cannot emphasize enough that there is no perfect time to introduce a lockdown.’  Several pundits have quoted the famous but misattributed Einstein saying; ‘Insanity is repeating the same thing over and over and expecting a different result.’

 

Deaths this week of two sporting heroes, Nobby Stiles, world cup winning footballer, and J J Williams, speedy Welsh rugby winger.

 

Tom Lehrer (still alive, but in his 90s), writer of wonderful and satirical songs, has released his oeuvre from copyright.  He is credited, when asked about Trump and modern political satire, as saying; ‘Political satire became obsolete when Henry Kissinger was awarded the Nobel peace prize.’  Many tributes also today to Sean Connery, the original and best James Bond, who has died at the age of 90.  A fine actor and patriotic Scot, but not patriotic enough to want to live in Scotland and pay Scottish taxes, preferring the Bahamas instead.  His memory perhaps also slightly sullied by Trump claiming that Connery intervened in the fuss over his wish to build one of his Scottish golf courses to allow him to proceed.  Also in the triviasphere today, Johnny Depp, film actor, loses his libel action against the Sun newspaper, who claimed he was a ‘Wife Beater’.  The Sun marked the passing of Sean Connery with a picture of his Bond persona and the tag line ‘Oh Oh Heaven.’

 

Tuesday November 3rd

 

Lockdown looms again.  November 5th.  Not a trace of irony it would seem.  ‘Remember, remember, the fifth of November…’  ‘Once the rockets are up, who cares where they come down.  That’s not my department says Werner von Braun.’  Grassroots sport, gym, everything, will be in abeyance, but those hugely overpaid footballers will still be in action.  Bobby Robson (Sir Bobby Robson) said: ‘”Twenty thousand a week?  I wouldn’t pay them twenty thousand a year.”  You have to remember he said that probably twenty years ago!  Multiply by around ten for current earnings.

 

At least today is clearer and sunnier after all that rain.  The United States goes to the polls today.  Footage of President Trump’s campaign visit to Fayetteville, North Carolina.  Huge, uncritical, unrelenting and unrepentant support for him there.  At Duke in the 1980s we used to call it ‘Fayette-nam’, an epithet coined for it because of its redneck character and the fact that it is essentially the city which is linked to the enormous U.S. army base of Fort Bragg (yes, named for a Confederate general).  Many of my colleagues at Duke used to moonlight down at the hospital there.  It gave them excellent experience of dealing with Friday and Saturday night violence and shootings.  A colleague told me an extraordinary story about his moonlighting there.  He was an Ivy leaguer (name withheld), who in college (name withheld), dated a very attractive woman, but they subsequently drifted apart.  Some years later, after he had married, he was attending an ambassador’s reception in Washington, where he met this girl who had obviously gone up in the world.  She looked a million dollars, was wearing the most expensive designer dress, festooned with diamonds, and was on the arm of a somewhat older Washington politician.  She greeted him warmly, and in response to questions about her career post Ivy league, she vaguely mentioned modelling and the movie industry.  My colleague was somewhat in awe and dumbfounded.  Back at Duke, he did the usual weekend sojourn down in Fayetteville.  Sleeping in the on-call doctor’s room, he idly turned to one of the provided magazines as reading material.  They were obviously intended for those intent on a solitary good time and suffering from Portnoy’s complaint.  Suddenly he found the ex-girlfriend within the pages.  Not only was she completely naked and indulging in a variety of sexual acts and unusual positions, but animals featured too.  A chastening experience, but just a flavour of what was on offer in Fayette-nam…

 

A relative in Pennsylvania has been shopping, not because of a lockdown on the horizon, but because he thinks it might be safer to stay indoors for a while after the U.S. election.  (I think that above juxtaposition as a figure of speech is called bathos).

 

Saturday November 7th

 

I had intended to write something about the U.S. election, but had no idea that it would drag on for so long – nearly 5 days now and counting; apparently there are still some votes to come in.  But it is clear that Biden has enough votes to be declared the 46th President of the United States.  The only person who disagrees it would seem is Donald Trump, who has threatened legal action to contest some of the individual state results.  But whether he goes quietly or loudly, it now seems certain that he will go.  A recent interview with a government minister by Andrew Neil, the highly intelligent and well informed TV journalist was a substantial grilling.  Neil pointed out that Trump was for Brexit while Biden was against Brexit.  I feel sure that a degree of pragmatism will attend any new White House regime, and Europe will be the least of his worries for the moment in such a deeply divided country.  In the meantime, an excellent article in the Business News of the Telegraph by Matthew Lynn states ‘Trumpism without Trump is what the world needs right now.’  He points out the very real economic achievements of the Trump administration (probably undertaken by some very savvy economic advisers rather than the Donald himself).  The Corporate Tax system, one of the least competitive in the world was reformed at a stroke.  The rate was cut from 35pc to 21pc, inviting corporate monies to return to the USA.  The rising tide of regulation was attacked – a slew of regulations was repealed.  Finally, enterprise zones did achieve the revitalisation of some (but not all) urban areas.  Other achievements include trade and continued improvement in volumes of trade with China.  As Lynn says, nobody is going to miss the bullying, the narcissism, or the temper tantrums.  Nobody will be sad to see the back of his divisive language, his ugly attitudes towards women, or his rambling attempts at rhetoric.  But…

 

Nonetheless, for me and for many the days of the deeply unattractive 45th President will hopefully soon be just an unpleasant memory.

 

In the meantime, the weather this week improved so that we had enjoyable autumn days with cold mornings but bright clear sunshine.  I seem to spend quite a lot of time on the obituary columns, but this is because I have reached an age where so many people who have taught me, who have formed my thinking as a physician and cardiologist, are leaving us.  This time it was the turn of Professor Peter Sleight, aged 91, Oxford cardiologist and researcher, who showed us that large scale trials could be done quite simply, if they were not exclusive.  The power of these trials came from the fact that their results could be generalised to all patients, and not just a highly select ‘safe’ treatment group.  A heart attack trial that I recruited for him (among many other hospitals) was presented at one of the big U.S. cardiology congresses in the early 1990s.  A famous American doctor stood up and said it was ‘low tech’, whereupon Peter took off his shoes and socks and presented at the lectern as what he called a ‘barefoot doctor.’  He was no respecter of reputations either.  He led a teach in on cardiac pacemakers for many of us senior registrars in Oxford one day.  A famous lady cardiologist vehemently expressed an opinion.  Peter asked her how many pacemakers her unit had put in in the last year.  The answer was about a fifth of what Oxford and some of the centres that we worked at was.  ‘So I think we can take it, …..,’, said the Prof, ‘That yours is a minority view.’  I enjoyed his company at meetings, in lectures, and on the golf course.  He was an original and stimulating thinker, and he challenged you.  His style of cardiac trial was rightly mentioned as being the forerunner of large simple trials such as the NHS study which has shown the value of dexamethasone in the treatment of Covid pneumonitis.  R.I.P.

 

It is time to finish this chapter of the Covid diary.  We are back in lockdown.  No golf, no pubs, no restaurants.  The tantalising prospect of a vaccine looms, we are told.  But not yet.

 

Meanwhile, as The Donald sinks slowly in the West, in a welter of lawsuits, we cannot like Malcolm report of the Thane of Cawdor, ‘Nothing in his Presidency became him like the leaving of it.’  (Macbeth).

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